Protein Details: Chloride channel protein 2

Protein ID

ICDB_Pro_0502

Protein Name

Chloride channel protein 2

Gene Name

Clcn2

Organism

Rattus norvegicus (Rat)

Length

907 amino acids

AlphaFoldDB

AF-P35525-F1-model_v4.pdb

Function

Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport . Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization; activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase; the rate-limiting enzyme for aldosterone biosynthesis (By similarity).

Sequence

MAAATAAAATVAGEGMEPRALQYEQTLMYGRYTQELGAFAKEEAARIRLGGPEPWKGSPSARATPELLEYGQSRCARCRICSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCLQAQQWMSRGLNTNILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMKKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEDLGAPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQKLRKAQMSPPSDQESPPSSETSIRFQVNTEDSGFPGAHGQTHKPLKPALKRGPSNATSLQEGTTGNMESAGIALRSLFCGSPPLESTTSELEKSESCDKRKLKRVRISLASDSDLEGKMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPRSRHGLPREGTPSDSDDKCQ

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Ubiquitously expressed

DOI ID

10.1038/356057a0; 10.1083/jcb.200204142; 10.1038/ncomms1871

RefSeq

NP_058833.1; XP_006248624.1